Skip to content
Authorized Re-Seller - Serving the Continental U.S. - Now offering FREE shipping on all orders over $95!
Authorized Re-Seller - Serving the Continental U.S. - Now offering FREE shipping on all orders over $95!

Large Briefs

Filters

$
$
Package of McKesson men's premium discreet underwear with a person wearing a white shirt and blue jeans.
$14.59 - $53.49
$14.59 - $53.49
$14.59 - $53.49
$14.59

McKesson Premium Discreet Heavy Men's Underwear, Gray, Large

in stock

McKesson Premium Discreet Heavy Men's Underwear – Large Model: McKesson Premium Discreet Heavy Availability: In Stock – Ready to Ship Shipping: ...

View full details
$14.59 - $53.49
$14.59 - $53.49
$14.59 - $53.49
$14.59
mckesson underwear
$14.99 - $54.88
$14.99 - $54.88
$14.99 - $54.88
$14.99

McKesson Discreet Men's Pull-On Underwear, Heavy Absorbency, Large, Gray

in stock

McKesson Discreet Men's Pull-On Underwear – Large Model: Discreet Men's Pull-On Underwear Availability: In Stock – Ready to Ship Shipping: Free ...

View full details
$14.99 - $54.88
$14.99 - $54.88
$14.99 - $54.88
$14.99
Package of Prevail daily underwear with product details on a blue and green background
$15.49 - $52.49
$15.49 - $52.49
$15.49 - $52.49
$15.49

Prevail Daily Underwear Maximum Pull-On - Large (44-58")

in stock

Prevail® Maximum Absorbency Unisex Underwear – Large Model: Prevail® Maximum Absorbency Series Availability: In Stock – Ready to Ship Shipping: ...

View full details
$15.49 - $52.49
$15.49 - $52.49
$15.49 - $52.49
$15.49
$29.99 - $58.99
$29.99 - $58.99
$29.99 - $58.99
$29.99

Depend Fresh Protection Women Underwear Large 48124

in stock

Depend Fresh Protection Women's Incontinence Underwear (Large) Model: Depend® Fresh Protection Women's Series SKU: 481...

View full details
$29.99 - $58.99
$29.99 - $58.99
$29.99 - $58.99
$29.99
Package of Cardinal Health Quilted Adult Briefs on a white background
$12.98 - $43.99
$12.98 - $43.99
$12.98 - $43.99
$12.98

Cardinal Health Wings Ultra Quilted Adult Incontinence Briefs (Size Large)

in stock

The Cardinal Health Wings™ Ultra Quilted Adult Briefs represent a premier, maximum-tier incontinence solution specifically engineered for individua...

View full details
$12.98 - $43.99
$12.98 - $43.99
$12.98 - $43.99
$12.98
TENA stretch brief packaging with a sample brief on a white background
$31.99 - $56.49
$31.99 - $56.49
$31.99 - $56.49
$31.99

TENA Stretch Plus Briefs - Large/X-Large (41-64 inch waist) - Moderate Absorbency

in stock

Most tabbed incontinence briefs present a binary care model: they either require full tab-change application by a caregiver, or they are pull-on un...

View full details
$31.99 - $56.49
$31.99 - $56.49
$31.99 - $56.49
$31.99
Package of Prevail Air Overnight briefs on a white background
$26.49 - $89.99
$26.49 - $89.99
$26.49 - $89.99
$26.49

Prevail Air Overnight Brief - Size 2/Large, Heavy Absorbency

in stock

Prevail Air Overnight Briefs (Size 2 / Large) Brand: Prevail Air Series (Manufacturer SKU: NGX-013) Product Type: Heavy/Overnight Tab...

View full details
$26.49 - $89.99
$26.49 - $89.99
$26.49 - $89.99
$26.49
MoliCare Premium Elastic bandage packaging with bandages on a white background
$45.99 - $119.99
$45.99 - $119.99
$45.99 - $119.99
$45.99

MoliCare Premium Elastic 8D – Unisex High-Capacity Briefs (Large)

in stock

MoliCare Premium Elastic 8D Briefs – Large Model: MoliCare Premium Elastic 8-Drop Availability: In Stock – Ready to Ship Shipping: Free Ground S...

View full details
$45.99 - $119.99
$45.99 - $119.99
$45.99 - $119.99
$45.99
MoliCare Premium Elastic packaging with product display on a white background
$51.99 - $143.99
$51.99 - $143.99
$51.99 - $143.99
$51.99

MoliCare Premium Elastic 6D – Unisex Moderate Absorbency Briefs (Large)

in stock

MoliCare Premium Elastic 6D Briefs – Large Model: MoliCare Premium Elastic 6-Drop Availability: In Stock – Ready to Ship Shipping: Free Ground S...

View full details
$51.99 - $143.99
$51.99 - $143.99
$51.99 - $143.99
$51.99
molicare briefs package with one open brief
$29.99 - $96.99
$29.99 - $96.99
$29.99 - $96.99
$29.99

MoliCare Premium Mobile 6D – Unisex Absorbent Underwear (Large)

in stock

MoliCare Premium Mobile 6D Underwear – Large Model: MoliCare Premium Mobile 6-Drop Availability: In Stock – Ready to Ship Shipping: Free Ground ...

View full details
$29.99 - $96.99
$29.99 - $96.99
$29.99 - $96.99
$29.99
$39.99 - $126.99
$39.99 - $126.99
$39.99 - $126.99
$39.99

MoliCare Premium Elastic 10D – Heavy Absorbency Briefs (Large)

Only 4 left!

MoliCare Premium Elastic 10D Briefs – Large Model: MoliCare Premium Elastic 10-Drop Availability: In Stock – Ready to Ship Shipping: Free Ground...

View full details
$39.99 - $126.99
$39.99 - $126.99
$39.99 - $126.99
$39.99
Package of Prevail overnight underwear on a white background
$14.29 - $47.99
$14.29 - $47.99
$14.29 - $47.99
$14.29

Prevail® Overnight Pull On Underwear Large unisex Heavy Absorbency

in stock

  Prevail Overnight Absorbency unisex Underwear Prevail® Overnight Absorbency unisex Underwear is designed for individuals who need **overnight or ...

View full details
$14.29 - $47.99
$14.29 - $47.99
$14.29 - $47.99
$14.29
Package of Prevail Per-Fit daily undergarments with purple and blue design
$12.49 - $51.49
$12.49 - $51.49
$12.49 - $51.49
$12.49

Prevail Per-Fit Women's Absorbent Underwear - Large, Moderate

in stock

Prevail Per-Fit Women's Protective Underwear Prevail Per-Fit Women's Protective Underwear is designed for women who prefer the familiar look and f...

View full details
$12.49 - $51.49
$12.49 - $51.49
$12.49 - $51.49
$12.49
Pack of McKesson women's premium discreet underwear with packaging details.
$14.99 - $54.99
$14.99 - $54.99
$14.99 - $54.99
$14.99

McKesson Premium Discreet Women's Absorbent Underwear, Maximum, Large

in stock

McKesson Premium Discreet Women's Underwear – Large Model: Premium Discreet Women's Underwear Availability: In Stock – Ready to Ship Shipping: F...

View full details
$14.99 - $54.99
$14.99 - $54.99
$14.99 - $54.99
$14.99
Gray boxer briefs worn by a person on a white background
$38.99 - $119.99
$38.99 - $119.99
$38.99 - $119.99
$38.99

Nexwear Men's Absorbent Underwear – Large (Gray)

in stock

Nexwear Men's Pull-On Underwear offers a discreet and reliable solution for daily protection and comfort. Designed specifically for the male anatom...

View full details
$38.99 - $119.99
$38.99 - $119.99
$38.99 - $119.99
$38.99
Package of McKesson Ultra Briefs on a white background
$7.39 - $46.99
$7.39
$13.99 - $46.99
$13.99 - $46.99
$13.99

McKesson Ultra Briefs Large Ultra Absorbency

in stock

McKesson Ultra Incontinence Briefs (Large) Model: McKesson Ultra Adult Brief Series Availability: In Stock – Ready to Ship Shipping: Free Ground...

View full details
$7.39 - $46.99
$7.39
$13.99 - $46.99
$13.99 - $46.99
$13.99
Package of McKesson Super Briefs on a white background
$12.79 - $39.99
$12.79 - $39.99
$12.79 - $39.99
$12.79

McKesson Super Brief Large

in stock

McKesson Super Incontinence Briefs (Large) Model: McKesson Super Adult Brief Series Availability: In Stock – Ready to ...

View full details
$12.79 - $39.99
$12.79 - $39.99
$12.79 - $39.99
$12.79
extended wear underwear
$15.00 - $52.99
$15.00 - $52.99
$15.00 - $52.99
$15.00

McKesson Extended Wear Absorbent Underwear – Large

in stock

McKesson Extended Wear Absorbent Underwear (Large) Model: McKesson Extended Wear Protective Pull-On Underwear Range Availability: In Stock – Rea...

View full details
$15.00 - $52.99
$15.00 - $52.99
$15.00 - $52.99
$15.00
Cardinal Health, adult Briefs, Wings™ Plus, Large, 45" - 58"
$14.99 - $48.99
$14.99 - $48.99
$14.99 - $48.99
$14.99

Cardinal Support day-to-day Wings™ Plus adult Briefs, Large (45"–58")

in stock

Item #: 6860034 | Manufacturer #: 60034 The Wings™ Plus adult Briefs by Cardinal Support day-to-day deliver superior protection and comfort for in...

View full details
$14.99 - $48.99
$14.99 - $48.99
$14.99 - $48.99
$14.99
adult incontinence briefs
$12.99 - $46.99
$12.99 - $46.99
$12.99 - $46.99
$12.99

Cardinal Support day-to-day Wings™ Basic Quilted adult Briefs, Large (45"–58")

in stock

Cardinal Support day-to-day Wings™ Basic Quilted adult Briefs, Large (45"–58")Item #: 6855034 | Manufacturer #: 55034 The Wings™ Basic Quilted adu...

View full details
$12.99 - $46.99
$12.99 - $46.99
$12.99 - $46.99
$12.99
Cardinal Health Sure Care Super Protective Underwear – Large, 44"–54"
$39.99 - $159.99
$39.99 - $159.99
$39.99
$19.99 - $73.99
$19.99 - $73.99
$19.99

Cardinal Sure Care Super Protective Underwear – Large, 44"–54"

in stock

Cardinal Sure Care Super Protective Underwear – Large, 44"–54" SKUs: 681215 (Pack of 16), 681215CS (Case of 64) Get advanced comfort and security w...

View full details
$39.99 - $159.99
$39.99 - $159.99
$39.99
$19.99 - $73.99
$19.99 - $73.99
$19.99
Attends briefs packaging with a white background
$19.00 - $49.99
$19.00 - $49.99
$19.00 - $49.99
$19.00

Attends® Incontinence Briefs Large (44"–58" Waist/Hip)

in stock

Attends Heavy Absorbency Premium Briefs (Large) Model: Attends® Maximum Protection Open Briefs Availability: In Stock – Ready to Ship Shipping: ...

View full details
$19.00 - $49.99
$19.00 - $49.99
$19.00 - $49.99
$19.00
Attends briefs packaging with a single brief displayed on a white background
$21.99 - $62.99
$21.99 - $62.99
$21.99 - $62.99
$21.99

Attends Care Advanced Incontinence Briefs - Heavy Absorbency, Large

in stock

Attends DermaDry Plus Premium Briefs (Large) Model: Attends® Care Advanced / DermaDry™ Plus Availability: In Stock – Ready to Ship Shipping: Fre...

View full details
$21.99 - $62.99
$21.99 - $62.99
$21.99 - $62.99
$21.99
Attends Briefs packaging with a sample brief on a white background
$54.99 - $54.99
$54.99
$54.99 - $54.99
$54.99

Attends Care Advanced Adult Incontinence Brief - Heavy Absorbency

in stock

Attends Care Advanced Heavy Protection Briefs (Large) Model: Attends® Care Advanced Series (Large) Availability: In Stock – Ready to Ship Shippi...

View full details
$54.99 - $54.99
$54.99
$54.99 - $54.99
$54.99

Large adult incontinence briefs are one of the most in-demand sizes on the market — and for good reason. For caregivers, family members, and individuals looking for a reliable, well-fitting brief that moves comfortably with the body, the large size strikes the balance between a secure fit and everyday wearability. Whether you're managing a daily routine at home or on the go, our large brief collection has you covered.

At EnhDme, we carry large adult incontinence briefs from trusted brands known for consistent sizing, quality absorbent cores, and skin-friendly materials. Our collection spans a wide range of absorbency levels and styles — so whether you need light daytime protection or heavy overnight coverage, you'll find a product that fits your needs and your lifestyle.

Did you know? Large is the single most purchased size in the adult incontinence brief category across the United States, making it the size with the widest product availability — and the most options to choose from when it comes to absorbency, style, and brand.

Our large briefs are sized to fit waist and hip measurements of approximately 45"–58" depending on the brand — always check the individual product size guide before ordering to confirm the best fit. With features like breathable side panels, refastenable tab closures, wetness indicators, and odor control, you'll find options suited for every routine and preference. Orders over $95 ship free, making it easy to keep a reliable supply on hand.

What You'll Find in This Collection

  • Disposable tab-style briefs
  • Light absorbency daytime briefs
  • Moderate absorbency briefs
  • Heavy absorbency briefs
  • Overnight / extended-wear briefs
  • Breathable, cloth-like outer cover briefs
  • Odor-control briefs
  • Latex-free & sensitive skin options

🚚 Free shipping on orders over $95 — EnhDme

Large Adult Briefs

Compare products

{"one"=>"Select 2 or 3 items to compare", "other"=>"{{ count }} of 3 items selected"}

Select first item to compare

Select second item to compare

Select third item to compare

Compare