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Authorized Re-Seller - Serving the Continental U.S. - Now offering FREE shipping on all orders over $95!
Authorized Re-Seller - Serving the Continental U.S. - Now offering FREE shipping on all orders over $95!

Large Briefs

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Package of McKesson men's premium discreet underwear with a person wearing a white shirt and blue jeans.
$14.59 - $53.49
$14.59 - $53.49
$14.59 - $53.49
$14.59

McKesson Premium Discreet Heavy Men's Underwear, Gray, Large

in stock

McKesson Premium Discreet Heavy Men's Underwear – Large Brand: McKesson Medical Supplies Product Style: Men's Disposab...

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$14.59 - $53.49
$14.59 - $53.49
$14.59 - $53.49
$14.59
mckesson underwear
$14.99 - $54.88
$14.99 - $54.88
$14.99 - $54.88
$14.99

McKesson Discreet Men's Pull-On Underwear, Heavy Absorbency, Large, Gray

in stock

McKesson Discreet Men's Pull-On Underwear – Large Brand: McKesson Medical Supplies Product Style: Men's Disposable Pul...

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$14.99 - $54.88
$14.99 - $54.88
$14.99 - $54.88
$14.99
tena complete care diapers
$15.99 - $56.99
$15.99 - $56.99
$15.99 - $56.99
$15.99

TENA Complete + Care Ultra Briefs Large – Blue

in stock

TENA Complete +Care Ultra Briefs – Large Brand: TENA® Complete +Care Ultra Series Product Style: Unisex Premium Tab-St...

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$15.99 - $56.99
$15.99 - $56.99
$15.99 - $56.99
$15.99
tena proskin brief - super
$43.87 - $87.76
$43.87 - $87.76
$43.87 - $87.76
$43.87

TENA ProSkin Super Overnight Incontinence Briefs, Large, Green

in stock

TENA ProSkin Super Overnight Briefs – Large Brand: TENA® ProSkin Super Overnight Series Product Style: Unisex Tab-Styl...

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$43.87 - $87.76
$43.87 - $87.76
$43.87 - $87.76
$43.87
TENA Dry Comfort product packaging on a white background
$60.49 - $60.49
$60.49
$60.49 - $60.49
$60.49

TENA Dry Comfort Moderate Absorbency Incontinence Brief - Large (40-56 inch waist)

in stock

TENA Dry Comfort Briefs – Moderate Absorbency (Case of 80) Brand: TENA® Dry Comfort™ Series Product Style: Unisex Tab-...

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$60.49 - $60.49
$60.49
$60.49 - $60.49
$60.49
Package of Prevail Breezers Daily Briefs with features highlighted on a white background
$16.49 - $57.99
$16.49 - $57.99
$16.49 - $57.99
$16.49

Prevail Breezers Briefs - Large (45-58 inch waist) - Heavy Absorbency

in stock

Prevail Breezers Briefs – Ultimate Heavy Absorbency Model: Prevail® Breezers® Adult Brief Series Availability: In ...

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$16.49 - $57.99
$16.49 - $57.99
$16.49 - $57.99
$16.49
TENA Complete Care product packaging with a brief displayed on a white background
$21.49 - $56.49
$21.49 - $56.49
$21.49 - $56.49
$21.49

TENA Complete + Care adult Incontinence Brief Large - Moderate Absorbency

in stock

TENA Complete +Care Adult Briefs – Large Model: TENA Complete +Care Series Availability: In Stock – Unisex Tab-Style Open Brief Design Moderate...

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$21.49 - $56.49
$21.49 - $56.49
$21.49 - $56.49
$21.49
prevail per-fit pack of 18
$15.49 - $52.99
$15.49 - $52.99
$15.49 - $52.99
$15.49

Prevail Per-Fit Maximum Plus adult Incontinence Brief - Large (45-58" Waist)

in stock

Prevail Per-Fit Maximum Plus Adult Briefs – Large Model: Prevail® Per-Fit® Maximum Plus Series Availability: In St...

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$15.49 - $52.99
$15.49 - $52.99
$15.49 - $52.99
$15.49
Pack of Seni Super Quatro briefs with packaging design on a white background
$18.49 - $64.99
$18.49 - $64.99
$18.49 - $64.99
$18.49

Seni® Super Quatro Overnight Incontinence Briefs – Large (Unisex)

in stock

Seni Super Quatro Briefs – Large Model: Seni® Super Quatro Breathable Brief Series (SKU # S-LA09-BQ1) Availability...

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$18.49 - $64.99
$18.49 - $64.99
$18.49 - $64.99
$18.49
Seni Classic Plus adult diaper packaging on a white background
$28.00 - $90.99
$28.00 - $90.99
$28.00 - $90.99
$28.00

Seni® Classic Plus Incontinence Briefs – Large (Unisex)

in stock

Seni Classic Plus Briefs – Large Model: Seni® Classic Plus Breathable Brief Series (SKU # S-LA25-BC2) Availability...

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$28.00 - $90.99
$28.00 - $90.99
$28.00 - $90.99
$28.00
Package of Seni Active Super Plus underwear on a white background
$12.79 - $46.99
$12.79 - $46.99
$12.79 - $46.99
$12.79

Seni Active Super Plus Adult Incontinence Underwear, Large, Heavy Absorbency, 39" - 53", 32 Count Case

in stock

Seni Active Super Plus Pull-On Underwear – Large Model: Seni Active Super Plus Breathable Pull-On Series (SKU # S-LA08-AP1...

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$12.79 - $46.99
$12.79 - $46.99
$12.79 - $46.99
$12.79
Pack of Seni Classic briefs with packaging details on a white background
$20.79 - $76.99
$20.79 - $76.99
$20.79 - $76.99
$20.79

Seni Classic Adult Incontinence Briefs, Regular, Moderate Absorbency, 40" - 50"

in stock

Seni Classic Briefs – Regular Model: Seni Classic Breathable Series (SKU # S-RE25-BC1) Availability: In Stock – Un...

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$20.79 - $76.99
$20.79 - $76.99
$20.79 - $76.99
$20.79
$28.49 - $141.99
$28.49 - $141.99
$28.49 - $141.99
$28.49

Abena® Premium Pants L2 - Heavy Absorbency Pull-On Underwear

in stock

Abena Pants Premium L2 Protective Pull-On Underwear – Large Model: Abena® Pants Premium L2 Series (39"–55" Hip Fitment) ...

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$28.49 - $141.99
$28.49 - $141.99
$28.49 - $141.99
$28.49
Attends Sleep Comfort premium overnight underwear packaging with a sample unit on a white background
$21.99 - $67.99
$21.99 - $67.99
$21.99 - $67.99
$21.99

Attends Sleep Comfort Premium Overnight Underwear Large

in stock

Attends Sleep Comfort Premium Overnight Underwear – Large Model: Attends® Sleep Comfort™ Premium Overnight Underwear Serie...

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$21.99 - $67.99
$21.99 - $67.99
$21.99 - $67.99
$21.99
Tena comfort pants
$5.69 - $59.99
$5.69 - $59.99
$5.69 - $59.99
$5.69

TENA ProSkin Comfort Pants Large/XL Green Waistband Reusable

in stock

TENA ProSkin Comfort Pants – Large / X-Large (Reusable) Model: TENA ProSkin™ High-Elasticity Seamless Fixation Series (Man...

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$5.69 - $59.99
$5.69 - $59.99
$5.69 - $59.99
$5.69
TENA Stretch diaper package for L/XL size on a white background
$23.99 - $74.99
$23.99 - $74.99
$23.99 - $74.99
$23.99

TENA Stretch Plus Briefs Large/XL Moderate Absorbency

in stock

TENA Stretch Plus Briefs – Large / X-Large – Moderate Absorbency Model: TENA Stretch™ Plus Everyday Tabbed Series (Manufac...

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$23.99 - $74.99
$23.99 - $74.99
$23.99 - $74.99
$23.99
Package of Prevail daily underwear with product details on a blue and green background
$15.49 - $52.49
$15.49 - $52.49
$15.49 - $52.49
$15.49

Prevail Daily Underwear Maximum Pull-On - Large (44-58")

in stock

Prevail® Maximum Absorbency Unisex Underwear – Large Model: Prevail® Maximum Absorbency Series Availability: In Stock – Ready to Ship Shipping: ...

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$15.49 - $52.49
$15.49 - $52.49
$15.49 - $52.49
$15.49
$29.99 - $58.99
$29.99 - $58.99
$29.99 - $58.99
$29.99

Depend Fresh Protection Women Underwear Large 48124

in stock

Depend Fresh Protection Women's Incontinence Underwear (Large) Model: Depend® Fresh Protection Women's Series SKU: 481...

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$29.99 - $58.99
$29.99 - $58.99
$29.99 - $58.99
$29.99
Package of Cardinal Health Quilted Adult Briefs on a white background
$12.98 - $43.99
$12.98 - $43.99
$12.98 - $43.99
$12.98

Cardinal Health Wings Ultra Quilted Adult Incontinence Briefs (Size Large)

in stock

The Cardinal Health Wings™ Ultra Quilted Adult Briefs represent a premier, maximum-tier incontinence solution specifically engineered for individua...

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$12.98 - $43.99
$12.98 - $43.99
$12.98 - $43.99
$12.98
TENA stretch brief packaging with a sample brief on a white background
$31.99 - $56.49
$31.99 - $56.49
$31.99 - $56.49
$31.99

TENA Stretch Plus Briefs - Large/X-Large (41-64 inch waist) - Moderate Absorbency

in stock

TENA Stretch Plus Briefs Brand: TENA® (Essity) Availability: In Stock – Unisex Hybrid Tabbed / Pull-Up Design ...

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$31.99 - $56.49
$31.99 - $56.49
$31.99 - $56.49
$31.99
Package of Prevail Air Overnight briefs on a white background
$26.49 - $89.99
$26.49 - $89.99
$26.49 - $89.99
$26.49

Prevail Air Overnight Brief - Size 2/Large, Heavy Absorbency

in stock

Prevail Air Overnight Briefs – Size 2 / Large Model: Prevail® Air Overnight Series (SKU # NGX-013) Availability: I...

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$26.49 - $89.99
$26.49 - $89.99
$26.49 - $89.99
$26.49
MoliCare Premium Elastic bandage packaging with bandages on a white background
$45.99 - $119.99
$45.99 - $119.99
$45.99 - $119.99
$45.99

MoliCare Premium Elastic 8D – Unisex High-Capacity Briefs (Large)

in stock

MoliCare Premium Elastic 8D Briefs – Large Brand: MoliCare / HARTMANN Product Style: Unisex Disposable Brief with Elas...

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$45.99 - $119.99
$45.99 - $119.99
$45.99 - $119.99
$45.99
MoliCare Premium Elastic packaging with product display on a white background
$51.99 - $143.99
$51.99 - $143.99
$51.99 - $143.99
$51.99

MoliCare Premium Elastic 6D – Unisex Moderate Absorbency Briefs (Large)

in stock

MoliCare Premium Elastic 6D Briefs – Large Brand: MoliCare / HARTMANN Product Style: Unisex Disposable Brief with Elas...

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$51.99 - $143.99
$51.99 - $143.99
$51.99 - $143.99
$51.99
molicare briefs package with one open brief
$29.99 - $96.99
$29.99 - $96.99
$29.99 - $96.99
$29.99

MoliCare Premium Mobile 6D – Unisex Absorbent Underwear (Large)

in stock

MoliCare Premium Mobile 6D Underwear – Large Brand: MoliCare / HARTMANN Product Style: Unisex Disposable Pull-On Prote...

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$29.99 - $96.99
$29.99 - $96.99
$29.99 - $96.99
$29.99

Large adult incontinence briefs are one of the most in-demand sizes on the market — and for good reason. For caregivers, family members, and individuals looking for a reliable, well-fitting brief that moves comfortably with the body, the large size strikes the balance between a secure fit and everyday wearability. Whether you're managing a daily routine at home or on the go, our large brief collection has you covered.

At EnhDme, we carry large adult incontinence briefs from trusted brands known for consistent sizing, quality absorbent cores, and skin-friendly materials. Our collection spans a wide range of absorbency levels and styles — so whether you need light daytime protection or heavy overnight coverage, you'll find a product that fits your needs and your lifestyle.

Did you know? Large is the single most purchased size in the adult incontinence brief category across the United States, making it the size with the widest product availability — and the most options to choose from when it comes to absorbency, style, and brand.

Our large briefs are sized to fit waist and hip measurements of approximately 45"–58" depending on the brand — always check the individual product size guide before ordering to confirm the best fit. With features like breathable side panels, refastenable tab closures, wetness indicators, and odor control, you'll find options suited for every routine and preference. Orders over $95 ship free, making it easy to keep a reliable supply on hand.

What You'll Find in This Collection

  • Disposable tab-style briefs
  • Light absorbency daytime briefs
  • Moderate absorbency briefs
  • Heavy absorbency briefs
  • Overnight / extended-wear briefs
  • Breathable, cloth-like outer cover briefs
  • Odor-control briefs
  • Latex-free & sensitive skin options

🚚 Free shipping on orders over $95 — EnhDme

Large Adult Briefs

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