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Now offering free shipping on orders over $95!

Large Briefs

Original price $14.59 - Original price $53.49
Original price
$14.59 - $53.49
$14.59 - $53.49
Current price $14.59

McKesson Premium Discreet Heavy Men's Underwear, Gray, Large

in stock

Discreet Heavy-Duty ProtectionMcKesson Premium Discreet Heavy Underwear provides a slim, form-fitting profile that mimics the look and feel of real...

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Original price $14.59 - Original price $53.49
Original price
$14.59 - $53.49
$14.59 - $53.49
Current price $14.59
Original price $14.99 - Original price $54.88
Original price
$14.99 - $54.88
$14.99 - $54.88
Current price $14.99

McKesson Discreet Men's Pull-On Underwear, Heavy Absorbency, Large, Gray

in stock

Stay confident and protected with McKesson Discreet Men's Pull-On Underwear. Designed to look and feel like regular underwear, these pull-ons featu...

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Original price $14.99 - Original price $54.88
Original price
$14.99 - $54.88
$14.99 - $54.88
Current price $14.99
Original price $31.99 - Original price $56.49
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$31.99 - $56.49
$31.99 - $56.49
Current price $31.99

TENA Stretch Plus Briefs - Large/X-Large (41-64 inch waist) - Moderate Absorbency

in stock

Most tabbed incontinence briefs present a binary care model: they either require full tab-change application by a caregiver, or they are pull-on un...

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Original price $31.99 - Original price $56.49
Original price
$31.99 - $56.49
$31.99 - $56.49
Current price $31.99
Original price $26.49 - Original price $89.99
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$26.49 - $89.99
$26.49 - $89.99
Current price $26.49

Prevail Air Overnight Brief - Size 2/Large, Heavy Absorbency

in stock

Overnight incontinence management is a fundamentally different problem than daytime management. During the day, changes can happen every 2–4 hours,...

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Original price $26.49 - Original price $89.99
Original price
$26.49 - $89.99
$26.49 - $89.99
Current price $26.49
Original price $45.99 - Original price $119.99
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$45.99 - $119.99
$45.99 - $119.99
Current price $45.99

MoliCare Premium Elastic 8D – Unisex High-Capacity Briefs (Large)

in stock

The MoliCare Premium Elastic 8D provides a reliable, high-capacity solution for those seeking maximum daily protection. Specifically designed for a...

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Original price $45.99 - Original price $119.99
Original price
$45.99 - $119.99
$45.99 - $119.99
Current price $45.99
Original price $51.99 - Original price $143.99
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$51.99 - $143.99
$51.99 - $143.99
Current price $51.99

MoliCare Premium Elastic 6D – Unisex Moderate Absorbency Briefs (Large)

in stock

The MoliCare Premium Elastic 6D is a high-quality, unisex solution for reliable daily protection. Featuring unique elasticated side panels, these L...

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Original price $51.99 - Original price $143.99
Original price
$51.99 - $143.99
$51.99 - $143.99
Current price $51.99
Original price $29.99 - Original price $96.99
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$29.99 - $96.99
$29.99 - $96.99
Current price $29.99

MoliCare Premium Mobile 6D – Unisex Absorbent Underwear (Large)

in stock

The MoliCare Premium Mobile 6D provides a discreet and reliable solution for individuals seeking daily protection with the look and feel of regular...

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Original price $29.99 - Original price $96.99
Original price
$29.99 - $96.99
$29.99 - $96.99
Current price $29.99
Original price $39.99 - Original price $126.99
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$39.99 - $126.99
$39.99 - $126.99
Current price $39.99

MoliCare Premium Elastic 10D – Heavy Absorbency Briefs (Large)

in stock

The MoliCare Premium Elastic 10D provides a professional-grade solution for those requiring maximum protection and skin-friendly comfort. These uni...

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Original price $39.99 - Original price $126.99
Original price
$39.99 - $126.99
$39.99 - $126.99
Current price $39.99
Original price $14.29 - Original price $47.99
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$14.29 - $47.99
$14.29 - $47.99
Current price $14.29

Prevail® Overnight Pull On Underwear Large unisex Heavy Absorbency

in stock

  Prevail Overnight Absorbency unisex Underwear Prevail® Overnight Absorbency unisex Underwear is designed for individuals who need **overnight or ...

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Original price $14.29 - Original price $47.99
Original price
$14.29 - $47.99
$14.29 - $47.99
Current price $14.29
Original price $12.49 - Original price $51.49
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$12.49 - $51.49
$12.49 - $51.49
Current price $12.49

Prevail Per-Fit Women's Absorbent Underwear - Large, Moderate

in stock

Prevail Per-Fit Women's Protective Underwear Prevail Per-Fit Women's Protective Underwear is designed for women who prefer the familiar look and f...

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Original price $12.49 - Original price $51.49
Original price
$12.49 - $51.49
$12.49 - $51.49
Current price $12.49
Original price $14.99 - Original price $54.99
Original price
$14.99 - $54.99
$14.99 - $54.99
Current price $14.99

McKesson Premium Discreet Women's Absorbent Underwear, Maximum, Large

in stock

Confidence meets comfort with McKesson Premium Discreet Women's Underwear. Specifically designed for the female anatomy, these pull-ons feature a s...

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Original price $14.99 - Original price $54.99
Original price
$14.99 - $54.99
$14.99 - $54.99
Current price $14.99
Original price $38.99 - Original price $119.99
Original price
$38.99 - $119.99
$38.99 - $119.99
Current price $38.99

Nexwear Men's Absorbent Underwear – Large (Gray)

in stock

Nexwear Men's Pull-On Underwear offers a discreet and reliable solution for daily protection and comfort. Designed specifically for the male anatom...

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Original price $38.99 - Original price $119.99
Original price
$38.99 - $119.99
$38.99 - $119.99
Current price $38.99
Original price $7.39 - Original price $46.99
Original price $7.39
$13.99 - $46.99
$13.99 - $46.99
Current price $13.99

McKesson Ultra Briefs Large Ultra Absorbency

in stock

McKesson Ultra Briefs – Large | Ultra AbsorbencyMcKesson Ultra Briefs provide reliable protection with advanced absorbency, comfort, and odor contr...

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Original price $7.39 - Original price $46.99
Original price $7.39
$13.99 - $46.99
$13.99 - $46.99
Current price $13.99
Original price $12.79 - Original price $39.99
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$12.79 - $39.99
Current price $12.79

McKesson Super Brief Large

in stock

McKesson Super Incontinence Briefs provide reliable moderate absorbency protection with refastenable tabs. This large size fits 44-58 inch waist/hi...

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Original price $12.79 - Original price $39.99
Original price
$12.79 - $39.99
$12.79 - $39.99
Current price $12.79
Original price $15.00 - Original price $52.99
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$15.00 - $52.99
$15.00 - $52.99
Current price $15.00

McKesson Extended Wear Absorbent Underwear – Large

in stock

McKesson Extended Wear Absorbent Underwear – Large | UWEXTLGProduct DescriptionMcKesson Extended Wear Absorbent Underwear (UWEXTLG) is designed for...

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Original price $15.00 - Original price $52.99
Original price
$15.00 - $52.99
$15.00 - $52.99
Current price $15.00
Original price $14.99 - Original price $48.99
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$14.99 - $48.99
$14.99 - $48.99
Current price $14.99

Cardinal Support day-to-day Wings™ Plus adult Briefs, Large (45"–58")

in stock

Item #: 6860034 | Manufacturer #: 60034 The Wings™ Plus adult Briefs by Cardinal Support day-to-day deliver superior protection and comfort for in...

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Original price $14.99 - Original price $48.99
Original price
$14.99 - $48.99
$14.99 - $48.99
Current price $14.99
Original price $12.99 - Original price $46.99
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$12.99 - $46.99
$12.99 - $46.99
Current price $12.99

Cardinal Support day-to-day Wings™ Basic Quilted adult Briefs, Large (45"–58")

in stock

Cardinal Support day-to-day Wings™ Basic Quilted adult Briefs, Large (45"–58")Item #: 6855034 | Manufacturer #: 55034 The Wings™ Basic Quilted adu...

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Original price $12.99 - Original price $46.99
Original price
$12.99 - $46.99
$12.99 - $46.99
Current price $12.99
Original price $39.99 - Original price $159.99
Original price $39.99 - Original price $159.99
Original price $39.99
$19.99 - $73.99
$19.99 - $73.99
Current price $19.99

Cardinal Sure Care Super Protective Underwear – Large, 44"–54"

in stock

Cardinal Sure Care Super Protective Underwear – Large, 44"–54" SKUs: 681215 (Pack of 16), 681215CS (Case of 64) Get advanced comfort and security w...

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Original price $39.99 - Original price $159.99
Original price $39.99 - Original price $159.99
Original price $39.99
$19.99 - $73.99
$19.99 - $73.99
Current price $19.99
Original price $19.00 - Original price $49.99
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$19.00 - $49.99
Current price $19.00

Attends® Incontinence Briefs Large (44"–58" Waist/Hip)

in stock

Maximum Absorbency Incontinence Briefs for Heavy to Severe ProtectionAttends Briefs with maximum absorbency are designed for users with heavy to se...

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Original price $19.00 - Original price $49.99
Original price
$19.00 - $49.99
$19.00 - $49.99
Current price $19.00
Original price $21.99 - Original price $62.99
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$21.99 - $62.99
$21.99 - $62.99
Current price $21.99

Attends Care Advanced Incontinence Briefs - Heavy Absorbency, Large

in stock

The Attends® Care Advanced (#DDP30)—also known as the DermaDry™ Plus line—is a premium brief designed for heavy incontinence. It features Advanced ...

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Original price $21.99 - Original price $62.99
Original price
$21.99 - $62.99
$21.99 - $62.99
Current price $21.99
Original price $41.99 - Original price $41.99
Original price
$41.99
$41.99 - $41.99
Current price $41.99

Attends Care Advanced adult Incontinence Brief Large Case of 72 - Heavy Absorbency

in stock

Enhanced protection with Attends Care Advanced Briefs featuring secureGrip fastening technology Professional-grade incontinence briefs designed for...

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Original price $41.99 - Original price $41.99
Original price
$41.99
$41.99 - $41.99
Current price $41.99
Original price $15.99 - Original price $43.99
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$15.99 - $43.99
$15.99 - $43.99
Current price $15.99

Attends Care Adult Absorbent Underwear Large

in stock

Attends Care Adult Absorbent Underwear - Large (44-58" Waist), Heavy AbsorbencyExperience reliable protection and comfort with Attends® Care absorb...

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Original price $15.99 - Original price $43.99
Original price
$15.99 - $43.99
$15.99 - $43.99
Current price $15.99
Original price $22.79 - Original price $64.80
Original price
$22.79 - $64.80
$22.79 - $64.80
Current price $22.79

Attends Adult Absorbent Underwear Large

in stock

Attends Adult Absorbent Underwear - Large (44-58" Waist), Maximum Heavy Absorbency Regain your independence with Attends® Protective Underwear. Des...

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Original price $22.79 - Original price $64.80
Original price
$22.79 - $64.80
$22.79 - $64.80
Current price $22.79
Original price $35.49 - Original price $81.99
Original price
$35.49 - $81.99
$35.49 - $81.99
Current price $35.49

Abri-Form™ Comfort L4 - Heavy Absorbency Incontinence Brief

in stock

One of the Most Absorbent All-In-One Briefs on the MarketThe Abri-Form™ Comfort L4 (#4168) is one of the most absorbent all-in-one briefs on the ma...

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Original price $35.49 - Original price $81.99
Original price
$35.49 - $81.99
$35.49 - $81.99
Current price $35.49

Large adult incontinence briefs are one of the most in-demand sizes on the market — and for good reason. For caregivers, family members, and individuals looking for a reliable, well-fitting brief that moves comfortably with the body, the large size strikes the balance between a secure fit and everyday wearability. Whether you're managing a daily routine at home or on the go, our large brief collection has you covered.

At EnhDme, we carry large adult incontinence briefs from trusted brands known for consistent sizing, quality absorbent cores, and skin-friendly materials. Our collection spans a wide range of absorbency levels and styles — so whether you need light daytime protection or heavy overnight coverage, you'll find a product that fits your needs and your lifestyle.

Did you know? Large is the single most purchased size in the adult incontinence brief category across the United States, making it the size with the widest product availability — and the most options to choose from when it comes to absorbency, style, and brand.

Our large briefs are sized to fit waist and hip measurements of approximately 45"–58" depending on the brand — always check the individual product size guide before ordering to confirm the best fit. With features like breathable side panels, refastenable tab closures, wetness indicators, and odor control, you'll find options suited for every routine and preference. Orders over $95 ship free, making it easy to keep a reliable supply on hand.

What You'll Find in This Collection

  • Disposable tab-style briefs
  • Light absorbency daytime briefs
  • Moderate absorbency briefs
  • Heavy absorbency briefs
  • Overnight / extended-wear briefs
  • Breathable, cloth-like outer cover briefs
  • Odor-control briefs
  • Latex-free & sensitive skin options

🚚 Free shipping on orders over $95 — EnhDme

Large Adult Briefs

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